Master/slave OCT

Master/slave (MS) represents a revival of the en-face view, whereby the values of the first OCT/SLO are re-enacted using the modern principles of spectral (or Fourier) domain OCT.

It is a technical invention of Applied Optics Group at the University of Kent. Prof Adrian Podoleanu and Dr Adrian Bradu are the inventors of this new imaging technique.

Since then, MS-OCT has been used extensively for both imaging and dispersion study in the UBAPHODESA project.

A few key points of this new Master Slave OCT are:

  • It operates like a time domain OCT, selecting signal from a selected depth while scanning the laser beam across the sample. Master Slave is a spectral (Fourier) domain OCT method, hence benefits from the sensitivity and speed advantage of the spectral (Fourier) domain methods in comparison with time domain method.
  • This method allows collection of signals from any number of depths, as required by the user, i.e. of any number of en-face OCT images, from any depths, separated by any distance from the neighboring en-face slices.
  • MS-OCT does not require resampling of data, hence no linearization, no calibration necessary, no clock needed in the swept source OCT, no linearized spectrometer in spectrometer based OCT

MSOCT_pigembryos

An illustration of MS-OCT technique in used for imaging pig embryo during early stage development. A 40 consecutive en-face (C-scan) can be viewed in one screen while simultaneous B-scan cross-section of the embryo is constructed at bottom right hand corner. (Image courtesy of Catherine Chin)

We have published a number of papers related to MS-OCT. This includes demonstration of technology and the application to clinical imaging by the UBAPHODESA team.

On clinical imaging:

  1. Catherine Chin, Adrian Bradu, Rongxuan Lim, Mona Khandwala, John Schofield, Lasse Leick, and Adrian Podoleanu, “Master/slave optical coherence tomography imaging of eyelid basal cell carcinoma,” Appl. Opt. 55, 7378-7386 (2016) [External OSA site]

On demonstration of techniques:

  1. Sylvain Rivet, Michael Maria, Adrian Bradu, Thomas Feuchter, Lasse Leick, and Adrian Podoleanu, “Complex master slave interferometry,” Opt. Express 24, 2885-2904 (2016)
  2. Adrian Bradu, Michael Maria, and Adrian Gh. Podoleanu, “Demonstration of tolerance to dispersion of master/slave interferometry,” Opt. Express 23, 14148-14161 (2015)

Papers from original development by inventors at Kent with links to external resources:

  1. Adrian Bradu, Sylvain Rivet, and Adrian Podoleanu, “Master/slave interferometry – ideal tool for coherence revival swept source optical coherence tomography,” Biomed. Opt. Express 7, 2453-2468 (2016)
  2. Adrian Gh. Podoleanu and Adrian Bradu, “Master–slave interferometry for parallel spectral domain interferometry sensing and versatile 3D optical coherence tomography,” Opt. Express 21, 19324-19338 (2013)
  3. Adrian Gh. Podoleanu and Adrian Bradu, “Master–slave interferometry for parallel spectral domain interferometry sensing and versatile 3D optical coherence tomography,” Opt. Express 21, 19324-19338 (2013)
  4. Adrian Bradu, Konstantin Kapinchev, Frederick Barnes, and Adrian Podoleanu, “Master slave en-face OCT/SLO,” Biomed. Opt. Express 6, 3655-3669 (2015)
  5. Adrian Bradu and Adrian Gh. Podoleanu, “Imaging the eye fundus with real-time en-face spectral domain optical coherence tomography,” Biomed. Opt. Express 5, 1233-1249 (2014)
  6. Adrian Bradu and Adrian Gh. Podoleanu, “Calibration-free B-scan images produced by master/slave optical coherence tomography,” Opt. Lett. 39, 450-453 (2014)
  7. Bradu A, Kapinchev K, Barnes F, Podoleanu A; “On the possibility of producing true real-time retinal cross-sectional images using a graphics processing unit enhanced master-slave optical coherence tomography system,” J. Biomed. Opt. 20(7), 076008 (2015)

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