May 3, 2016

Catherine Chin

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Project title, ESR2: Intrinsic fluorescence excited with SC, noise, dispersion and polarisation-sensitive OCT

Aiming to improve medical diagnosis through development of optical tomography imaging systems using ultra wideband light sources.

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Current projects and research areas

  • Retinal decoding using a high powered supercontinuum light
    • Marmalian physiological response to light stimulus
    • Decoding circadian retina signalling

Motivation

 Low coherence non-contact scanning interferometer like OCT uses collinear laser beam based on reflectometry principles. Analyses of backscattered signals from a balanced detector give useful information on depth, polarisation and intensity, and are used widely in medical diagnosis. Ability to extract these features in living subjects requires integration of broadband laser sources, such as high power super continuum (SC) and broadband UV lasers from NKT Photonics.

To achieve sub-micron axial range in an OCT requires broadband optical source. However, essential in achieving high axial resolutions for functional imaging, several other important parameters need to be addressed. My current research is dedicated to investigating influence of noise, dispersion, and polarisation of optical sources on microscope assembled OCT configurations.

 


 

Outreach activities


Professional Experience

2014 to present
Canterbury, UK
 Researcher (University of Kent)
  • Development of low-noise concept for broadband optical sources with balance heterodyne detection
  • Design and implementation of polarisation selection and phase decoding for OCT input
  • Improved time-domain OCT system for clinical imaging
  • Worked with camera based spectrometer system for high resolution optical imaging
  • Implement multimodal functional imaging system by combining flourescence, confocal and dual-channel OCT system
  • Characterisation of dispersion in optical system with a novel narrowline acousto-optic tunable filter module
  • Devised an automated retina imaging system with broadband supercontinuum light to study pupillary light reflex in mouse
  • Participated in performance analyses of en-face OCT and master/slave imaging on clinical tissues
2012 to 2013
Okinawa, Japan
  • Developed two optical pump and terahertz probe optical spectroscopy systems
  • Generation of ultra broadband 20 THz wave using advanced LT interdigitated photoconductive antennas and non-linear electro-optic crystals
  • Generation of mid-infrared and deep UV conversion using high-energy optical parametric amplifiers.
  • Characterisation of ultrafast dynamics in 2D heterostructure materials such as TiO2, graphene, hBN and MoS2
  • Implement a novel drug delivery system to study sub-second neurotransmitter dynamics with femtosecond lasers
  • Devised an automated high precision temperature controlled feedback monitoring system for ultrafast laboratory

 


Education

  • 2014 to 2017      PhD in Physics      University of Kent, UK
  • 2013 to 2014      Masters of Science in Telecoms     Telecom Bretagne, France
  • 2006 to 2010      Bachelor of Engineering in Electronics     Multimedia University, Malaysia

Publications

  1. Catherine Chin, Florin Toadere, Thomas Feuchter, Lasse Leick, Peter Moselund, Adrian Bradu,  and Adrian Podoleanu, Acousto-optic tunable filter for dispersion characterization of time-domain optical coherence tomography systems, Applied Optics Vol. 55, Issue 21, pp. 5707-5714 (2016)
  2. Catherine Chin, Adrian Bradu, Rongxuan Lim, Mona Khandwala, John Schofield, Lasse Leick, and Adrian Podoleanu, Master/slave optical coherence tomography imaging of eyelid basal cell carcinoma, Applied Optics Vol. 55, Issue 25, 7378-7386 (2016)