May 3, 2016

Sophie Caujolle

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Project title, ESR3: Ultra broadband system for histology and submicron resolution of cells

Aiming to combine both interest in medical science and optics by working on a non-invasive imaging system with micron resolution.

Current projects and research areas

  • Ultra-broadband Optical Coherence Tomography for submicron resolution
  • Phase sensitivity OCT
  • OCT Angiography
  • Fourier-domain, and master-slave OCT configurations



In the early nineties, a new optical method based on low-coherence interferometry called Optical Coherence Tomography (OCT) was developed. 
This non-invasive imaging method has been widespread in ophthalmology over the past decades thanks to its ability to visualize ocular structures at high resolution in lateral and axial direction.

To improve even better axial resolution, the use of ultra-broadband source is needed such as a supercontinuum source from NKT Photonics. Although this system is able to provide good visual structural data, doctors want more by asking to add different kind of information. Therefore, there is a strong pull for OCT to move from structural imaging to functional imaging to add additional information to the morphological information, like polarization sensitive OCT, spectroscopic OCT, elastographic OCT and so forth.
Age-related macular degeneration, glaucoma and diabetic retinopathy are the three main causes for visual field loss and blindness. These diseases have an impact on blood vessels such as the presence of choroidal neovacularization, a reduction or complication in retinal blood flow. Currently, the gold standard for imaging the vasculature network is Fluorescein Angiography (FA) and Indocyanine Green Angiography (IGA). However, both are invasive and require intraveneous dye injections.
OCT angiography is a solution providing superficial and deep vascular plexuses. This method solves the previous mentioned issues from FA and IGA. In this project, different methods from phase sentivity OCT to speckle variance OCT are investigated.


Professional Experience

  • 2016 – present: Canterbury, UK
    [PhD] Researcher – University of Kent
  • 2014 – 2016: Birkerod, Denmark
    [PhD] Researcher – NKT Photonics A/S
  • April – September 2014: Vienna, Austria
    [Master thesis] Setting up a Thermal Light Source for Spectral Domain Optical Coherence Tomography – Center of Medical Physics and Biomedical Engineering
  • November – March 2014: Jena, Germany
    [Research Labwork Optic] Below 50 nm BaTiO3 core-shell nanoparticles for biological application – Institute for Applied Physics



  • 2013 – 2014: Friedrich-Schiller-Universität Jena
    Master’s degree, Photonic – Germany
  • 2011 – 2014 : ENSSAT
    Master’s degree, Optronics Engineering – France
  • 2008 – 2011: Lycée les Eucalyptus
    Bachelor’s degree in Physics – France